First published in the early 2000s, Cell Signalling Biology is an outstanding online resource describing the biology of cell signalling, including:
A helpful and detailed overview of the fundamentals of cell signalling
Must-know information on each signalling pathway that is condensed into a concise and clear format via cell signalling maps
Illustration of how biological processes are regulated
Explanation of how disruptions in control pathways cause human diseases
Over 150 cell signalling pathways are outlined across 12 'modules'
This resource is freely available to all, and is especially relevant to researchers, teachers and students in the cellular life sciences
About the Author
Graduating from the University College of Rhodesia and Nyasaland, Rhodesia, in 1960 with First Class Honours, he attained his PhD at the University of Cambridge, UK, in 1965. He then carried out postdoctoral research in the USA (University of Virginia and Case Western Reserve University) before returning to Cambridge in 1969 to take up a position with the Agricultural and Food Research Council's (AFRC) Unit of Invertebrate Chemistry and Physiology, based in the University's Zoology Department.
After a long professional association with the Babraham Institute he formally joined the Laboratory of Molecular Signalling at the Babraham Institute in 1990. He is a fellow of Trinity College and was elected a fellow of the Royal Society in 1984. In 1997, he was knighted in the New Year's Honours list for his contributions to science.
Watch a special Biochemistry Society Centenary interview 'The key that unlocked calcium' in which Professor Sir Michael Berridge talks to Professor Robin Irvine about his Eureka moment in calcium signalling and his passion for trying to find the solution to interesting problems.
Shaw Laureate in Life Science and Medicine 2005
In September 2005 Professor Berridge was awarded the prestigious Shaw Prize (hailed as the Nobel Prize of the East) for his pioneering work in the field of cell signalling. His discovery of the key role that calcium plays in regulating cellular activity and orchestrating the complexities of cellular communication has given insight into some of the physiological processes behind medical conditions such as hypertension, cardiac arrhythmia and heart failure, cancer and bipolar disorders such as manic depressive illness.
Professor Berridge's discovery of the molecule inositol trisphosphate (IP3), and its role in the calcium signalling pathway, was a major breakthrough in understanding how a cell translates chemical stimuli at its external surface into an intracellular chemical language that enables the cell to elicit a physiological response. These breakthroughs have had a profound influence on diverse areas of biomedical research such as cell proliferation, fertilization, neural activity, memory and learning, metabolism and muscle contraction.